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PD ISO/TR 23463:2022 Nanotechnologies. Characterization of carbon nanotube and carbon nanofiber aerosols in relation to inhalation toxicity tests, 2022
- National foreword
- Foreword
- Introduction
- 1 Scope
- 2 Normative references
- 3 Terms and definitions
- 4 Abbreviated terms
- 5 Considerations in CNT and CNF inhalation studies [Go to Page]
- 5.1 General
- 5.2 Workplace exposure scenario
- 5.3 Existing inhalation toxicity testing guidelines
- 6 Physicochemical parameters related to the toxicity of CNTs and CNFs [Go to Page]
- 6.1 General
- 6.2 Aerodynamic properties of aerosols for deposition of fibres
- 6.3 Size and shape (including length, width, aspect ratio, state of aggregation/agglomeration, and rigidity)
- 6.4 Specific surface area
- 6.5 Crystalline structure and defects
- 6.6 Surface chemistry, functionalization, surface charge, impurities, and radical generation/scavenging potential
- 6.7 Biodurability
- 7 Issues for the characterization of CNT and CNF aerosols [Go to Page]
- 7.1 General
- 7.2 Characterization of physicochemical properties of CNT and CNF prior to aerosol generation [Go to Page]
- 7.2.1 General
- 7.2.2 Size and size distribution
- 7.2.3 Shape (rigidity and agglomeration/aggregation)
- 7.2.4 Surface area
- 7.2.5 Crystalline structures
- 7.2.6 Surface chemistry, functionalization, surface charge, and radical generation/scavenging potential
- 7.2.7 Composition, purity, and impurities
- 7.2.8 Biodurability (in vivo and in vitro tests)
- 7.3 CNT and CNF aerosol characterization (sampling and measurement) [Go to Page]
- 7.3.1 General
- 7.3.2 Size and size distribution of CNT and CNF aerosols
- 7.3.3 The shape of CNT and CNF aerosols
- 7.3.4 Crystalline structure and defects
- 7.3.5 Surface chemistry
- 7.3.6 Composition analysis
- 7.3.7 Fibre density
- 7.3.8 Concentration
- 7.4 Direct and indirect measurement [Go to Page]
- 7.4.1 Direct measurement
- 7.4.2 Indirect measurement
- Annex A (informative) Physicochemical properties of CNT associated with biological activity
- Annex B (informative) CNT and CNF aerosol monitoring instruments
- Bibliography [Go to Page]
